Monday, August 27, 2007

Ectopic calcifications

Right mineral (calcium), wrong spot (skin, muscles, tendons, etc.). KGMom commented on a possible connection between the class of drugs called bisphosphonates (Fosamax, Actonel, Boniva, Reclast) and calcifications in the body.

I'd not read of such a connection, so I looked it up on PubMed. No articles reported a connection between the drug and ectopic calcifications. In fact, check this out:

Bisphosphonates are an old class of compounds. They were used in the 1930s as antiscaling and anticorrosion agents in washing powders and water to prevent the deposition of calcium crystals. Those basic functions were later utilized in an attempt to prevent ectopic calcifications in humans. The early studies demonstrated that bisphosphonates had a strong affinity for bone. That property was first exploited when the compounds were used for "bone scans." Currently, the drugs are used for treatment of hypercalcemic conditions, abnormal bone remodeling, Paget disease, malignancy, and osteoporosis.
--Rodd, C. Peritoneal Dialysis Int. 2001;21 Suppl 3:S256-60.

Now how do you feel about a year-long injection of an antiscaling agent? Amazing where these drugs come from.

1 comment:

KGMom said...

Oh my goodness--very interesting. You are right--who knew these drugs came from such long ago applications.
Hmmm--is this a good development or not?